Introduction to glutaraldehyde disinfectant

- Aug 21, 2018 -

Glutaraldehyde disinfectant is a new type of high-efficiency, low-toxic neutral-strength disinfectant that kills pathogenic microorganisms such as bacterial propagules, bacterial spores, and hepatitis germs.

Glutaraldehyde kills microorganisms mainly through its two active aldehyde groups; its activity is affected by factors such as pH and temperature; glutaraldehyde is hydrolyzed to monohydrate, dihydrate, and ring under acidic conditions. Hemi-acetal and a polymer similar to acetal, which are balanced with each other; due to the small amount of glutaraldehyde monomer present in the acidic aqueous solution, its biological activity is poor; but under acidic conditions, The polymerization of aldehydes is slow, so that acidic glutaraldehyde is relatively stable and can be stored for a long period of time. Under acidic conditions, increasing the temperature produces more free aldehyde groups, thereby increasing its biological activity.

Glutaraldehyde has high biological activity under alkaline conditions of pH 7.5-8.5, which can kill all microorganisms including spores; glutaraldehyde can be polymerized into butyl aldols under alkaline conditions. The polymer is then formed into a higher polymerization form; in an aqueous alkaline solution, the polymerization of glutaraldehyde is irreversible, and as the polymer gradually increases, its activity gradually weakens or disappears; alkaline glutaraldehyde follows pH and Increasing the temperature and prolonging the storage time can lead to enhanced polymerization and thus a reduction in activity. Therefore, alkaline glutaraldehyde activity is strong, but the effective period is generally only two weeks; acid glutaraldehyde activity is weak, but the effective period is longer, up to 1 month.