The development of glutaraldehyde

- Aug 10, 2018-

Glutaraldehyde is known as the third milestone in the history of the development of chemical disinfectants following the sterilization of formaldehyde and ethylene oxide. As a raw liquid for the production of glutaraldehyde series fungicides, this product has the characteristics of low methanol content, no disproportionation and no accumulation of poison, and is widely used in disinfection and sterilization, pharmaceutical and other industries. Glutaraldehyde is a highly effective disinfectant with broad spectrum, high efficiency, low toxicity, low corrosiveness to metals, little influence by organic matter, and stability.

Good character and other characteristics. It is suitable for disinfection and sterilization of medical instruments and precision instruments resistant to dampness. The sterilization concentration is 2%, and the commercially available glutaraldehyde mainly includes 2% basic glutaraldehyde and 2% strengthened acid glutaraldehyde. Alkaline glutaraldehyde is often used for sterilization of medical devices. Before use, an appropriate amount of sodium hydrogencarbonate should be added. After shaking, it is allowed to stand for 1 hour, and the pH is measured. When the pH is 7.5-8.5, glutaraldehyde has the strongest bactericidal effect. Glutaraldehyde sterilization is the function of its monomer. When the pH of the solution reaches 6, the monomer has a tendency to polymerize. As the pH rises, the polymerization is extremely rapid, and precipitation occurs in the solution, which is lost after the formation of the polymer.

Sterilization. Therefore, alkaline glutaraldehyde is a relatively unstable disinfectant, and 2% fortified acid glutaraldehyde is a polyoxyethylene fatty alcohol ether as a strengthening agent, which enhances the sterilization of glutaraldehyde. Its pH is lower than 5, its killing effect on bacterial spores is weaker than alkaline glutaraldehyde, but it is stronger than alkaline glutaraldehyde, and its stability is better than alkaline glutaraldehyde. It can be used continuously. 28 days.

(1) Sterilization principle: The killing effect of aldehyde disinfectant on microorganisms mainly depends on aldehyde group. These drugs mainly act on the base, hydroxyl, carboxyl and amino groups of bacterial proteins, which can be alkylated and cause protein coagulation. Causes bacterial death.

(2) Main advantages and disadvantages: advantages:

1 Glutaraldehyde is a broad-spectrum, high-efficiency disinfectant that can kill all microorganisms;

2 can be used for sterilization of heat-resistant medical devices;

3 glutaraldehyde has low irritation, low corrosivity, safety and low toxicity at the use concentration;

4 is less affected by organic matter, 20% of organic matter has little effect on the bactericidal effect. Disadvantages:

1 sterilization time is long, sterilization is generally up to 10 hours;

2 glutaraldehyde has a certain toxicity, can cause bronchitis and pulmonary edema;

3 The sterilized medical device needs to be thoroughly rinsed with distilled water before use.

(3) Sterilization:

Alkaline glutaraldehyde is a broad-spectrum, high-efficiency disinfectant that can effectively kill various microorganisms and thus can be used as a sterilizing agent, but the effect of strengthening acid glutaraldehyde to kill spores is weak.